Microvesicles and neutrophil aggression factors in the pathogenesis of chronic periodontitis

Background. It is known that the number of polymorphonuclear leukocytes increases with development periodontitis. However, their role in pathogenesis chronic periodontitis has not been fully defined.
 Aim. To study pathogenetic periodontitis, realized by microvesicles and aggression factors (metalloproteinases, myeloperoxidase, calprotectin, lipocaine 2).
 Material methods. 30 patients aged to 50 years a diagnosis generalized moderate severity (K05.3) no severe somatic pathology were under observation. The comparison group included 20 people inflammatory diseases oral cavity, comparable main terms gender, age, nationality, presence bad habits. Using standard set indices, state periodontal tissues was assessed, all examined underwent X-ray examination. In fluid examined, total phenotype, concentration matrix metalloproteinases-2 -9, 2 determined. parameters determined using flow cytometer. Descriptive statistics are represented median interquartile range (25th 75th percentiles). Two independent sample sets compared MannWhitney test. Correlation analysis carried out according Spearman method.
 Results. 11 times higher than healthy volunteers (p=0.00001). More third them had neutrophil markers. levels also correlated value index, depth pocket, bleeding indicators health. Thus, strong positive relationship found between index (r=0.675), pocket (r=0.763), (r=0.704); neutrophilic health r=0.816, r=0.837 r=0.776, respectively. content metalloproteinase-2 (r=0.754), (r=0.811), papillary-marginal-alveolar (r=0.675).
 Conclusion. Neutrophils contribute through secretion factors: metalloproteinases, 2, microvesicles.